Introduction Next-Generation Sequencing (NGS) has become a foundational technology in genomics research. Despite the advances in sequencing accuracy and variant callers, false positive variants remain a significant issue in both whole genome and whole exome sequencing analyses. Traditionally, researchers rely on manual review using tools such as the Integrative Genomics Viewer (IGV) to filter out

A groundbreaking study published in Nature Materials presents a computational framework for creating bifaceted protein nanomaterials—also known as Janus protein nanoparticles—with independently addressable faces. This approach overcomes the limitations of traditional symmetric protein designs, which preclude functional differentiation across particle surfaces. 1. Introduction & Design Rationale Traditional nanoparticle designs rely on high symmetry and identical