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Cypin Regulates Synaptic Content via K63-linked Polyubiquitination: A New Layer in Synaptic Plasticity

A new study reveals a novel function for the cytosolic protein Cypin in regulating synaptic composition and function via K63-linked polyubiquitination—an underexplored post-translational modification in neurons. The work answers key questions about how specific ubiquitin chains modulate synaptic targeting and turnover, offering insights with therapeutic potential. Proposed model: Cypin modulates synaptic signaling by regulating proteasome […]

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RibbonFold: Generating Amyloid Polymorph Landscapes with AI

Amyloid fibrils are central to neurodegenerative diseases like Alzheimer’s and Parkinson’s. However, predicting their structures is notoriously difficult because, unlike most proteins that fold into a single stable form, amyloids exhibit extreme polymorphism: a single sequence can fold into multiple distinct, stable structures depending on conditions. Existing tools like AlphaFold2, designed for monomeric, soluble proteins,

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VariFAST: Automated Variant Filtering by Tagged-Signatures

Introduction Next-Generation Sequencing (NGS) has become a foundational technology in genomics research. Despite the advances in sequencing accuracy and variant callers, false positive variants remain a significant issue in both whole genome and whole exome sequencing analyses. Traditionally, researchers rely on manual review using tools such as the Integrative Genomics Viewer (IGV) to filter out

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Bifaceted Protein Nanomaterials: Computational Design and Colocalization

A groundbreaking study published in Nature Materials presents a computational framework for creating bifaceted protein nanomaterials—also known as Janus protein nanoparticles—with independently addressable faces. This approach overcomes the limitations of traditional symmetric protein designs, which preclude functional differentiation across particle surfaces. 1. Introduction & Design Rationale Traditional nanoparticle designs rely on high symmetry and identical

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Sumoylation: Mechanisms, Functions, and Biological Significance

Small Ubiquitin-like Modifier (SUMO) refers to a family of small proteins that function as post-translational modifiers, primarily affecting the behavior and fate of target proteins. SUMOylation is evolutionarily conserved and found in all eukaryotic cells. Classification and Structural Features SUMO is a ubiquitin-like protein, sharing ~18% sequence similarity with ubiquitin and possessing the characteristic β-grasp

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